I'm really excited to share this study I came across the other day on inositol arginine silicate - one of the key ingredients in my new Superpump 3.0! This ingredient generates massive pumps and that's why I included in the new formula. I promised to use only the most effective ingredients and this new study proves what everyone who has tried SuperPump 3.0 already knows:
The purpose of this study was to characterize the PK/PD of Nitrosigine™, an inositol-stabilized arginine silicate dietary supplement. Ten healthy males, 26.7 ± 5.4 years, took Nitrosigine™ qd for 14 days and attended test visits on Days 1 and 14. Fasting blood and saliva collections were performed pre-dose and at 0.5, 1, 1.5, 2, 3, 4, 5 and 6 hours post-dose for plasma arginine, serum silicon and salivary nitric oxide + nitrite (NO). After Day 1 dose, arginine levels increased (p<0.01) at 0.5, 1, 1.5, 2, 3 and 5 hours and silicon levels increased (p<0.05) at 1 and 1.5 hours. Day 1 PK parameters for arginine were: CMax 27.25±4.86 µg/ml and tMax 1.05±0.50 and for silicon: CMax 2.77±0.74 µg/ml and tMax 2.15±1.75. After Day 14 dose, arginine levels increased (p<0.05) at 0.5, 1, and 1.5 hours, and silicon levels increased (p<0.01) at 1, 1.5, 2, and 3 hours. After 14 days of use, baseline arginine trended towards being higher than baseline Day 1 (p=0.0645), and 4-hour post-dose plasma arginine was significantly higher (p=0.0488). Although not a significant difference, NO increased in four subjects and stayed the same in six subjects at 0.5 hours after the first dose (p=0.125). After 14 days of use, baseline NO levels increased in six subjects and stayed the same in four subjects (p=0.031). No safety concerns were raised by this study.